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KMID : 1161420210240121264
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Journal of Medicinal Food
2021 Volume.24 No. 12 p.1264 ~ p.1270
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Green Tea Extract Increases Soluble RAGE and Improves Renal Function in Patients with Diabetic Nephropathy
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Barocio-Pantoja Marycruz
Quezada-Fernandez Patricia
Cardona-Muller David
Jimenez-Cazarez Mayra B.
Larios-Cardenas Mariana
Gonzalez-Radillo Oscar I.
Garcia-Sanchez Andres
Carmona-Huerta Jaime
Chavez-Guzman Ana N.
Diaz-Preciado Paul A.
Balleza-Alejandri Ricardo
Pascoe-Gonzalez Sara
Grover-Paez Fernando
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Abstract
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One of the proposed mechanisms for the development of diabetic nephropathy (DN) is the increase of end products of advanced glycosylation (AGEs), which bind to its receptor (RAGE), favoring nephron cellular damage. An isoform of this receptor is soluble RAGE (sRAGE), which can antagonize AGE-altered intracellular signaling. It has known that green tea extract (GTE) increases the expression of sRAGE, but it is unknown whether this could improve kidney function. The objective of this study was to evaluate the effect of the administration of GTE on the concentrations of sRAGE, renal function, and metabolic profile in patients with type 2 diabetes mellitus (T2DM) and DN. A randomized, double-blinded, placebo-controlled clinical trial was carried out in 39 patients who received GTE (400?mg every 12?h) or placebo for 3 months. sRAGE levels, renal function, and metabolic parameters were determined before and after the intervention. In the GTE group, there were statistically significant increase on sRAGE (320.55?±?157.63?pg/mL vs. 357.59?±?144.99?pg/mL; P?=?.04) and glomerular filtration rate (GFR; 66.44?±?15.17?mL/min/1.73?m2 vs. 71.70?±?19.33?mL/min/1.73?m2; P?=?.04), and a statistically significant decrease in fasting serum glucose (7.62?±?3.00?mmol/L vs. 5.86?±?1.36?mmol/L; P?≤?.01) and triacylglycerols (1.91?±?0.76?mmol/L vs. 1.58?±?0.69; P?=?.02). Administration of GTE increases the serum concentration of sRAGE and the GFR and decreases the concentration of fasting serum glucose and triacylglycerols. The study was registered in ClinicalTrials.gov with the identifier NCT03622762.
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KEYWORD
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AGE-RAGE, glomerular filtration rate, green tea, kidney damage, metabolic profile
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